Product Name :
presenilin 1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
AD3 antibody Ad3h antibody FAD antibody Homo Sapiens Clone CC44 Senilin 1 antibody Presenilin-1 CTF12 antibody Protein S182 antibody PS 1 antibody PS-1 antibody PS1-CTF12 antibody PSEN1 antibody 展开
Function :
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human Presenilin-1 NTF subunit 10-80/467
Species reactivity:
Human, Mouse, Rat, Dog, Pig, Cow, Rabbit
Verify application:
WB, ELISA, IHC-P, FC, IF, ICC
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.BuyBrettPhos Pd G4 When reconstituted in sterile pH 7.AN-12-H5 intermediate-1 site 4 0.PMID:33583390 01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
34/52 KDa
Positive control :
Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.