p53 (acetyl K370) Recombinant Rabbit Monoclonal Antibody [SR40-09]

Function :
p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms.Price of (4-Aminobutyl)dimethylamine p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2.1919022-57-3 uses MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation.PMID:33715257 Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.